The December 2008 issue of Drug and Therapeutics Bulletin (DTB) has two articles. The first is a review of the two HPV vaccines, ▼Gardasil and ▼Cervarix. The second article reviews ▼zolendronic acid, a bisphosponate licensed for treatment of patients with osteoporosis that requires only a once-yearly intravenous administration. The issue also contains a reminder that a full list of those people that we would like to thank for their contribution to our articles this year can be found on our website www.dtb.bmj.com.